Inhibition of Milk Kinin Activity by Phenolic Antioxidants

Inhibition of myeloperoxidase-catalyzed tyrosylation by phenolic antioxidants in vitro.

We have developed an in vitro assay system for the evaluation of the inhibitory effects of phenolic antioxidants on myeloperoxidase (MPO) activity. The formation of dityrosine from the MPO/H2O2/L-tyrosine system was used as an indicator of the MPO activity. Because the buffer system used does not include chloride ion, this assay has the advantage of exclusion of direct reaction between an antio...

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

Induction of phase 2 detoxification enzymes by phenolic antioxidants can account for prevention of tumor initiation but cannot explain why these compounds inhibit tumor promotion. Phase 2 genes are induced through an antioxidant response element (ARE). Although the ARE resembles an AP-1 binding site, we show that the major ARE binding and activating protein is not AP-1. Interestingly, AP-1 DNA ...

Phenolic antioxidants.

Phenolic Compounds, Antioxidants and Antibacterial Activity of Some Native Medicinal Plants Against Pseudomonas aeruginosa

Background & Objective: Traditional medicines have a wide range of pharmacological properties. This work was aimed to investigate the antimicrobial effect of Thymus vulgaris, Matricaria chamomilla, Melissa officinalis and Rhus coriaria extracts against clinical isolates of Pseudomonas aeruginosa. Materials and Methods: 180 P. aeruginosa clinical isolates were examined. disc diffusion method as...

Angiogenesis inhibition by antioxidants

Reducing cancer morbidity and mortality requires several synergic approaches target on tumoural cells and their environment. Angiogenesis is the development of new blood vessels from the pre-existing vasculature. This process is normally observed only transiently during embryogenesis, and in adulthood, during wound healing and uterus function. However, pathologic angiogenesis is involved in som...